Isosorbidi Mononitras [Latin]
Brand names,
Isosorbidi Mononitras [Latin]
Analogs
Isosorbidi Mononitras [Latin]
Brand Names Mixture
Isosorbidi Mononitras [Latin]
Chemical_Formula
C6H9NO6
Isosorbidi Mononitras [Latin]
RX_link
http://www.rxlist.com/cgi/generic/isomono2.htm
Isosorbidi Mononitras [Latin]
fda sheet
Isosorbidi Mononitras [Latin]
msds (material safety sheet)
Isosorbidi Mononitras [Latin]
Synthesis Reference
Hayward et al., Can.J.Chem., 45; 2191-2192 (1967)
Isosorbidi Mononitras [Latin]
Molecular Weight
191.139 g/mol
Isosorbidi Mononitras [Latin]
Melting Point
88-91oC
Isosorbidi Mononitras [Latin]
H2O Solubility
1.07E+005 mg/L
Isosorbidi Mononitras [Latin]
State
Solid
Isosorbidi Mononitras [Latin]
LogP
-0.15
Isosorbidi Mononitras [Latin]
Dosage Forms
Tablet (immediate release); Tablet (extended release)
Isosorbidi Mononitras [Latin]
Indication
For the prevention of angina pectoris due to coronary artery disease and the treatment of acute and chronic angina pectoris, hypertension, and myocardial infarction.
Isosorbidi Mononitras [Latin]
Pharmacology
Isosorbide-5-mononitrate, the long-acting metabolite of isosorbide dinitrate, is used as a vasodilatory agent in the management of angina pectoris. By dilating the vessels, it lowers the blood pressure and reduces the left ventricular preload and afterload, therefore, leads to a reduction of myocardial oxygen requirement.
Isosorbidi Mononitras [Latin]
Absorption
100%
Isosorbidi Mononitras [Latin]
side effects and Toxicity
Symptoms of overdose include vasodilatation, venous pooling, reduced cardiac output, and hypotension. LD50=mg/kg(orally in rat)
Isosorbidi Mononitras [Latin]
Patient Information
Isosorbidi Mononitras [Latin]
Organisms Affected
Humans and other mammals